A new study was approached by Martin Friedlander and colleagues, at the Scripps Institute, La Jolla, suggesting a simpler way to reduce VEGF induced blood vessel in the eye which causes vision loss.
In most disease, vision loss is caused, when the permeability of blood vessels in the retina of eye is alerted by other factors (e.g, fluid accumulating in the retina impairing eyesight). Molecule VEGF is a initiator of increased blood vessel permeability. If VEGF antagonists stabilizes, the eyesight of some patients can be improved. But this treatment requires repeated injection of the VEGF antagonist into the eye which is a painful procedure.
Martin Friedlander and colleagues found a small molecule inhibitor of signaling molecules that associate with the receptors of VEGF (known as Src kinases). This molecule can eliminate VEGF induced accumulation of fluid in the retina of mice and rabbits. The effect was observed when the inhibitor was both injected intravenously and used as an eye drop.
Now, they are trying to use this approach to benefit individuals who are suffering from many disease which are caused due to vision loss through VEGF-induced increased blood vessel permeability.
Source: Look to the future: New drug reduces one cause of vision loss