Risk of Nuclear Cataract Reduced by Statin

The statins are associated with a lower incidence of nuclear cataract, the most common type of age-related cataract.

Statins are widely used to decrease serum cholesterol for cardiovascular disease prevention.
Statins have also been shown to have antioxidant activity. Oxidative stress ( a condition in which antioxidant levels are lower than normal ) has been thought to be a risk factor for age-related cataract, particularly nuclear cataract. Some evidence has suggested an association between nutritional intake of antioxidants and age-related cataract.

A total of 210 persons developed incident nuclear cataract in the interval from 1998-2000 to 2003-2005.
The five-year incidence of nuclear cataract was 12.2 percent in statin users compared with 17.2 percent in nonusers; the odds of developing cataract were 40 percent lower for statin users after adjusting for several factors.

Source: Journal of American Medical Association, 2006


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