Revolutionary Treatment for Eye Cancer Retinoblastoma革命性的治療癌症的眼睛視網膜母細胞瘤
A new locally applied treatment for the eye cancer retinoblastoma has been developed by scientists at St. Jude Children's Research Hospital and demonstrated in a mouse model to cause a remarkable reduction in the size of the tumor, without causing the side effects common with standard chemotherapy.一個新的局部應用治療眼視網膜母細胞瘤的癌症已開發出科學家在聖裘德兒童研究醫院，並展示了一個小鼠模型，以造成顯著地減少腫瘤大小，而不致造成副作用，常見的與標準化療。 A report on this work appears in the Nov. 2 issue of the journal Nature.報告對這項工作，出現在11月2日發行的Nature雜誌上。
In addition the treatment also appears to be suitable for certain forms of breast, lung, prostate and colon cancer, and is simple enough for widespread use even in countries with limited resources.此外待遇似乎也適合某些形式的乳腺癌，肺癌，前列腺癌和結腸癌，很簡單，為廣泛使用，甚至在資源有限的國家。
Retinoblastoma occurs in about 5,000 young children worldwide each year, arising from the immature retina, which is the part of the eye responsible for detecting light and color.視網膜母細胞瘤發生在大約5000名青少年兒童全世界每年產生的未成熟視網膜，這是部分的眼睛負責探測光，色。 The cancer is fatal if left untreated.癌症是致命的，如果離開未處理。
The treatment is based on a discovery by Dyer's laboratory that overturned a widely held belief about the process of apoptosis (cell suicide) in retinoblastoma.治療是基於對發現代爾的實驗室推翻了廣泛持有的信念約的過程中細胞凋亡（細胞自殺） ，在視網膜母細胞瘤。 Apoptosis is the way the body rids itself of abnormal cells that might become cancerous or cause other problems.細胞凋亡是這樣的身體擺脫不正常的細胞，有可能成為癌症或引起其他問題。
Until now, retinoblastoma experts thought that a mechanism called the p53 pathway triggered apoptosis in other types of cancer cells, but not in retinoblastoma.目前為止，視網膜母細胞瘤的專家們認為，一個機制稱為p53途徑引發細胞凋亡的其他類型的癌細胞，而不是在視網膜母細胞瘤。
However, the St. Jude team proved not only that the p53 pathway was activated in early-stage retinoblastoma, but that excessive levels of a molecule called MDMX blocked it from triggering apoptosis in more advanced tumors.然而，聖裘德隊證明這不僅使p53途徑被激活，在早期階段，視網膜母細胞瘤，但過量的分子mdmx阻擋它引發細胞凋亡的較先進的腫瘤。
Based on this discovery, the St. Jude team used a molecule called nutlin-3 to block MDMX in retinoblastoma cells in test tube studies as well as in mouse models.基於這一發現，聖裘德隊用了一個分子所謂nutlin - 3座mdmx在視網膜母細胞在試管研究，以及在小鼠模型。
The molecule was originally developed by Roche Pharmaceuticals (Nutley, NJ) for a similar use against a related target called MDM2 in adult cancer.分子原本是由羅氏製藥（ nutley ，新澤西州） ，為類似的使用對一個相關目標所謂MDM2在成人癌症。
Source: Medical News Today資料來源：醫療新聞今天
For more information, please visit http://www.stjude.org.如需更多資訊，請瀏覽http://www.stjude.org 。
St. Jude Children's Research Hospital聖裘德兒童研究醫院的
332 N. Lauderdale St., Mail Stop 761 332 12月31日Lauderdale的聖，郵件停止761
Memphis, TN 38122孟菲斯，總氮38122
United States美國
http://www.stjude.org
You may also like to read您可能還喜歡讀
- Antibiotic Fights Lymphoma of Eye Linked to Chlamydia抗生素打架淋巴瘤的眼睛相連衣原體
- Researchers Tracked Origins of a Form of Eye Cancer - Uveal Melanoma研究者追踪起源的一種形式的眼癌-黑素瘤葡萄膜
- Radiation helps eye cancer patients beat the disease, retain vision輻射有助於眼部癌症患者戰勝疾病，保持視野
- Revolutionary Stem Cell Treatment Could Restore Lost Sight革命性的幹細胞治療，可以恢復丟失的視線
- Antibiotic Doxycycline Successfully Treats Eye Lymphoma抗生素強力黴素成功待人眼淋巴瘤
- Early Detection of Deadly Eye Disease Saves Child's Life早期發現的致命性眼病節省孩子的生命
- New Vision Correction Surgery (Second Generation Optical Implants) Debuts in Madison, Wisconsin新的矯正視力手術（第二代光學植入物）亮相麥迪遜威斯康辛
- Princeton Eye Group Revolutionizes Cataract Surgery in Central New Jersey普林斯頓大學眼科集團改變了白內障手術，在中央新球衣
- Eye Problems Resulting From Albinism眼科問題造成的白化病
- Laser Surgery Cures Blindness Of A Glaucoma Affected Horse激光手術治療的盲目性一個青光眼影響馬匹
