Revolutionary Treatment for Eye Cancer Retinoblastoma革命性的治疗癌症的眼睛视网膜母细胞瘤
A new locally applied treatment for the eye cancer retinoblastoma has been developed by scientists at St. Jude Children's Research Hospital and demonstrated in a mouse model to cause a remarkable reduction in the size of the tumor, without causing the side effects common with standard chemotherapy.一个新的本地应用治疗眼癌的视网膜母细胞瘤已开发的科学家在圣裘德儿童研究医院的，显示了在一个小鼠模型，以事业的显着减少，在肿瘤大小，不会造成副作用，常见的与标准化疗。 A report on this work appears in the Nov. 2 issue of the journal Nature.一份报告，这项工作将出现在11月2日问题的Nature杂志上。
In addition the treatment also appears to be suitable for certain forms of breast, lung, prostate and colon cancer, and is simple enough for widespread use even in countries with limited resources.此外，治疗似乎也适合某些形式的乳腺癌，肺癌，前列腺癌和结肠癌，很简单，不够广泛使用，甚至在资源有限的国家。
Retinoblastoma occurs in about 5,000 young children worldwide each year, arising from the immature retina, which is the part of the eye responsible for detecting light and color.视网膜母细胞瘤发生在约5000年幼子女，每年全球，所产生的从不成熟的视网膜，这是部分的眼睛负责侦查轻和颜色。 The cancer is fatal if left untreated.癌症是致命的，如果得不到治疗。
The treatment is based on a discovery by Dyer's laboratory that overturned a widely held belief about the process of apoptosis (cell suicide) in retinoblastoma.治疗是基于对发现戴尔的实验室推翻了广泛持有的信念约的过程中细胞凋亡（细胞自杀）在视网膜母细胞瘤。 Apoptosis is the way the body rids itself of abnormal cells that might become cancerous or cause other problems.细胞凋亡是这样的身体肋本身的不正常的细胞有可能成为癌变或导致其他问题。
Until now, retinoblastoma experts thought that a mechanism called the p53 pathway triggered apoptosis in other types of cancer cells, but not in retinoblastoma.直至目前为止，视网膜母细胞瘤的专家认为，一个机制，所谓的p53通路引发细胞凋亡的其他类型的癌细胞，但不是在视网膜母细胞瘤。
However, the St. Jude team proved not only that the p53 pathway was activated in early-stage retinoblastoma, but that excessive levels of a molecule called MDMX blocked it from triggering apoptosis in more advanced tumors.然而，圣裘德队证明，不仅如此， p53蛋白通路被激活，在早期阶段的视网膜母细胞瘤，但过度的水平了一种分子，叫做mdmx阻止它从触发细胞凋亡的更先进的肿瘤。
Based on this discovery, the St. Jude team used a molecule called nutlin-3 to block MDMX in retinoblastoma cells in test tube studies as well as in mouse models.在此基础上发现，圣裘德小组使用了一种分子，叫做nutlin - 3座mdmx在视网膜母细胞瘤细胞在试管研究，以及在小鼠模型。
The molecule was originally developed by Roche Pharmaceuticals (Nutley, NJ) for a similar use against a related target called MDM2 in adult cancer.分子原本开发的罗氏制药（ nutley ，新泽西州）一个类似的使用对一个相关的目标，所谓的MDM2在成人癌症。
Source: Medical News Today资料来源：今日医疗新闻
For more information, please visit http://www.stjude.org.如需详细资讯，请造访http://www.stjude.org 。
St. Jude Children's Research Hospital圣裘德儿童研究医院的
332 N. Lauderdale St., Mail Stop 761 332 12月31日劳德代尔堡圣，邮件停止761
Memphis, TN 38122孟菲斯，田纳西州38122
United States美国
http://www.stjude.org
Filed under提起下 Eye Treatment眼科治疗 | |
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