Revolutionary Treatment for Eye Cancer Retinoblastoma
A new locally applied treatment for the eye cancer retinoblastoma has been developed by scientists at St. Jude Children's Research Hospital and demonstrated in a mouse model to cause a remarkable reduction in the size of the tumor, without causing the side effects common with standard chemotherapy. A report on this work appears in the Nov. 2 issue of the journal Nature.
In addition the treatment also appears to be suitable for certain forms of breast, lung, prostate and colon cancer, and is simple enough for widespread use even in countries with limited resources.
Retinoblastoma occurs in about 5,000 young children worldwide each year, arising from the immature retina, which is the part of the eye responsible for detecting light and color. The cancer is fatal if left untreated.
The treatment is based on a discovery by Dyer's laboratory that overturned a widely held belief about the process of apoptosis (cell suicide) in retinoblastoma. Apoptosis is the way the body rids itself of abnormal cells that might become cancerous or cause other problems.
Until now, retinoblastoma experts thought that a mechanism called the p53 pathway triggered apoptosis in other types of cancer cells, but not in retinoblastoma.
However, the St. Jude team proved not only that the p53 pathway was activated in early-stage retinoblastoma, but that excessive levels of a molecule called MDMX blocked it from triggering apoptosis in more advanced tumors.
Based on this discovery, the St. Jude team used a molecule called nutlin-3 to block MDMX in retinoblastoma cells in test tube studies as well as in mouse models.
The molecule was originally developed by Roche Pharmaceuticals (Nutley, N.J.) for a similar use against a related target called MDM2 in adult cancer.
Source: Medical News Today
For more information, please visit http://www.stjude.org.
St. Jude Children's Research Hospital
332 N. Lauderdale St., Mail Stop 761
Memphis, TN 38122
United States
http://www.stjude.org
Filed under Eye Treatment
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