Researchers Tracked Origins of a Form of Eye Cancer - Uveal Melanoma

Researchers at West Virginia University have tracked the origins of a form of eye cancer, Uveal Melanoma, that often leads to the removal of the eye and death.

The research may lead to new treatments for the cancer, said Joginder Nath, professor of genetics and developmental biology at WVU. Nath, along with former doctoral students Jason White and Alison Myska, recently published their findings in two genetics journals.

Geneticists have taken the research as far as they can, and now it is up to oncologists to find ways to use the information to treat patients, Nath said.

Researchers compared the cells using two types of fluorescent labeling of DNA to determine how many copies of the DNA there were. Another technique involved tracking the physical rearrangement of chromosomes in a tumor cell. The tumor is usually not detected until vision is impaired and it has grown quite large, that means the patient often loses their eye and by that time often the cancer has spread to the liver, and once that occurs, prognosis is quite poor.

The research should lead to new treatment techniques but won't likely help with early detection, Nath said.

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