Phase II Clinical Trial of Mifepristone an Eye Drop Treatment for Steroid Associated Elevated Intraocular Pressure
Global bio-nanotech company pSivida Limited (NASDAQ:PSDV) (ASX:PSD) (Xetra:PSI) today announced the initiation of a Phase II clinical trial of Mifepristone (otherwise known as RU486) as an eye drop treatment for steroid associated elevated intraocular pressure (IOP).
The investigator-sponsored trial will involve up to 45 patients in the United States. pSivida will be supplying clinical trial material for this study and has filed a patent application on this product class.
Elevated IOP may occur in patients receiving steroidal treatment for chronic eye diseases. The trial will investigate the use of Mifepristone as a means to prevent elevation of IOP from intraocular steroid exposure. Mifepristone is a steroid receptor antagonist ("steroid blocker") already approved by the FDA. This study represents a potential new use of an existing drug, made possible by a new delivery system.
Filed under Eye Treatment
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February 16th, 2008 at 6:57 am
very little market for this drug
February 16th, 2008 at 9:50 am
no much use for this drug
August 26th, 2008 at 5:51 am
I think it’s a marvellous step forward. So many people suffer from IOP due to use of corticosteroids used for a variety of medical conditions and IOP is one of those side-effects. Makes sense to prevent IOP via topical application. I use the drug 200mg daily for another medical condition and it’s safe, no side-effects even for use at that daily dose. Would absolutely recommend it as a safe and effective medication for various medical condtions. Those who claim there is no market for the drug don’t understand it.