Lissamine green Shows Promise In Dry Eye Detection麗絲膠綠皮書顯示，承諾在乾眼症的檢測
Dry eye syndrome is one of the most common eye ailments.幹眼綜合徵是一種最常見的眼科疾病。 According to various estimates, it affects 10 percent to 30 percent of the world's population, including 10 million to 14 million Americans — mostly older women.根據不同的估計，它影響到10 ％到30 ％的世界人口，其中包括1000萬至14萬美國人-主要是老年婦女。 Symptoms include eyes that burn or sting, blurred vision, frequent blinking, light sensitivity or a sandy or gritty feeling like something is in the eye.症狀包括眼睛燒傷或螫，視力模糊，頻繁眨眼，對光線敏感，或沙質或gritty的感覺一樣的東西是在眼睛。
Lissamine green, an eye-drop stain is used by ophthalmologists to detect damaged cells on the eye's surface, flagging them green under special lighting.麗絲膠綠色，滴眼液染色所使用的眼科醫生來偵測受損細胞對眼睛的表面上，他們的綠色標幟下，特別照明。
"What this research showed is that the degree and pattern of staining was a good, objective indicator of the severity of the tear deficiency," said Dr. James McCulley, chairman of ophthalmology at UT Southwestern and one of the world's leading experts on dry eyes. “這項研究顯示，是程度和模式的染色是一個很好的，客觀的指標的嚴重程度，淚液不足，博士說： ”詹姆斯mcculley主席，眼科在對西南地區之一，世界領先的專家就幹眼。
In a study by Dr. McCulley and his colleagues found that the severity of the dry eye condition in patients correlates with where the stain patterns show up.在一項研究博士mcculley和他的同事們發現的嚴重程度，乾眼症患者的條件與相關的地方染色模式顯示出來。 Those basic patterns are:這些基本模式是：
* The least-severe condition is indicated by stains limited to the whites of the eyes between the lids toward the nose. *至少重度的條件是所顯示的污漬有限公司向眼白之間的蓋子對牽著鼻子走。 This so-called nasal staining doesn't necessarily predict dry eye: it might be caused by environmental factors, such as pollution.這個所謂的鼻腔染色，不一定預測乾眼症的：它可能造成的環境因素，如污染。
* The second level appears as stains in the white of the eye between the lids, but toward the ear. *第二個層次出現污漬，在白色的眼睛之間的蓋子，但對耳朵。 "That is fairly diagnostic of a tear deficiency," Dr. McCulley said. “這是相當診斷一個催淚不足， ”博士mcculley說。
* The third and most severe level occurs when the stain also appears on the cornea. *第三和最嚴重的水平時，就會發生染色似乎也對眼角膜。
"That's when things really get serious," said Dr. McCulley, the study's senior author. “的，當事情真正嚴重，醫生說： ” mcculley ，該研究報告的資深作者。 "If the dry eye is significantly affecting the cornea, it deteriorates vision and adds a major risk factor for a person developing a bad infection." “如果乾眼症是顯著影響角膜，它惡化的遠見和增加的一個主要危險因素對一個人發展一個壞的感染” 。
"When the surface is healthy, we're protected against the vast majority of bacteria. But if there's a compromise of the surface, then bacteria can invade," said Dr. McCulley, who said the investigation was inspired by his many years observing staining patterns in the patients he treated. “當表面上是健康的，我們正在對受保護的絕大多數細菌，但如果有一個妥協的表面，然後細菌能夠入侵，博士說： ” mcculley ，世衛組織說，這項調查的啟發，他多年觀察染色模式在病人他治療。
Researchers examined the stain patterns in 22 patients with varying degrees of dry eyes and 11 patients without ocular disease, who served as control subjects.研究人員研究了染色模式，在22例不同程度的幹眼及11例無眼病，曾經擔任美國控制的科目。 The research not only revealed the progressive pattern, but also underscored the value of using lissamine green stain over the more commonly used fluorescein stain, which doesn't easily identify damage until it is more progressed.研究不僅揭示了漸進式模式，但也強調應用價值麗絲膠綠染色比較常用的熒光染色，這並不容易確定損壞，直至它更多的進展。
"If an ophthalmologist uses the most commonly used stain, which is fluorescein, they're going to miss the first two stages of the development of dry eye and consequently miss a lot of diagnoses," said Dr. McCulley, director of the Theodore and Mary Beasley Laboratory for Ocular Surface Research and the Jean H. & John T. Walter Jr. Center for Research in Age-Related Macular Degeneration. “如果一個眼科醫生使用最常用的污點，這是熒光，他們要去錯過了前兩個階段的發展，乾眼症，並因此錯過了很多的診斷，醫生說： ” mcculley ，主任的西奧多和瑪麗比斯利實驗室眼表面的研究和讓每小時＆約翰沃爾特小湯匙，研究中心在年齡相關性黃斑變性。
"The more severe stage is not only more problematic in affecting vision, but it is more difficult to treat and reverse," Dr. McCulley said. “更嚴厲的階段，不僅是更多的問題，影響視野，但更難以治療和扭轉， ”博士mcculley說。 "So it's very important to diagnose at the mild stages because it can become a self perpetuating disease if not effectively treated." “所以這是非常重要的診斷在溫和的階段，因為它可以成為一個自我延續的疾病如果沒有有效的治療” 。
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